明治薬科大学
分子製剤学研究室
明治薬科大学
分子製剤学研究室

研究業績

2025

原著論文 Original Articles

  1. Relationship between phase transition and drug release of Doxorubicin-encapsulated liposomes with different lipid compositions using Raman spectroscopy: Yamada R, Sato T, Haneishi K, Hisada H, Fujii Yoshimura M, Hirota K, Koide Ta, Fukami T (aDivision of Drugs, National Institute of Health Sciences), Biol. Pharm. Bull., accepted (2025).
  2. Evaluation of the film-forming ability for heparinoid cream formulations: Shikamura Na, Fukami T , Koide Tb, Yamamoto Ya, (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bDivision of Drugs, National Institute of Health Sciences), Chem. Pharm. Bull., 73, 852-856 (2025).
  3. The rational selection for solubilized formulation technologies utilizing physicochemical properties: Kimoto Ka, Yamamoto Ka, Fukami T, Ikeda Ya (aTakeda Pharmaceutical Company Limited), Chem. Pharm. Bull., 73, 857-867 (2025).
  4. Nano-Scale Screening of Amorphous Solid Dispersion and Its Stability with Monitoring Phase Transition Using Low-Frequency Raman Spectroscopy: Haku R, Suzuki Na, Ohashi K, Titapiwatanakun Vb, Fukami T (aSchool of Pharmacy, Nihon University, bFaculty of Pharmaceutical Sciences, Chulalongkorn University), J. Drug Deliv. Sci. Technol., 112, 107237 (2025).
  5. Physical Properties for Novel Cilostazol Co-amorphous ; Effect of preparation method and molar ratio on the co-amorphous: Takayama T, Kaneko Sa, Palanisamy V, Ono M, Titapiwatanakun Vb, Higashi Ka, Fukami T (aGraduate School of Pharmaceutical Sciences, Chiba University, bFaculty of Pharmaceutical Sciences, Chulalongkorn University), Chem. Pharm. Bull., 73, 318-326 (2025). https://doi.org/10.1248/cpb.c24-00732
  6. Pharmaceutical Evaluation of Magnesium Oxide Fine Granule Formulation for Conversion to Magnesium Hydroxide owing to Humidification by Near-Infrared Spectroscopy: Yamamoto Ya, Mitani Ma, Fukami T, Koide Tb (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bDivision of Drugs, National Institute of Health Sciences), Vib. Spectrosc., 138, 103801 (2025). https://doi.org/10.1016/j.vibspec.2025.103801
  7. Elucidating molecular state of loxoprofen in acrylic adhesive patches which could relate transdermal drug permeability: Haraguchi N, Watanabe Y, Shimazaki Ma, Fujii Yoshimura M, Palanisamy V, Fukami T (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University), Chem. Pharm. Bull., 73, 298-306 (2025). https://doi.org/10.1248/cpb.c23-00853
  8. Multicomponent Solid Forms of Pioglitazone and Their Influence on Drug Dissolution: Shimada N, Uchida H, Palanisamy V, Chernyshev Va, Fukami T (aDepartment of Chemistry, M. V. Lomonosov Moscow State University), Cryst. Growth Des., 25, 1514-1525 (2025). https://doi.org/10.1021/acs.cgd.4c01617
  9. In-situ Monitoring of Dissolution and Crystallization Processes of Carbamazepine using Low-frequency Raman Spectroscopy and Multivariate Analysis: Kudo T, Uchida H, Yamato M, Ohashi R, Palanisamy V, Fukami T, Chem. Pharm. Bull., 73, 58-62 (2025). https://doi.org/10.1248/cpb.c24-00745
  10. Optimization of formulation and device design for carrier-based nasal powder of influenza vaccine to maximize the delivery capability to the target site in the nasal cavity: Mieda Sa, Inoue Ka, Ito Aa, Yada Sa, Fukami T (aDaiichi Sankyo Co., Ltd.), J. Drug Deliv. Sci. Technol., 104, 106454 (2025). https://doi.org/10.1016/j.jddst.2024.106454


2024

原著論文 Original Articles

  1. Monitoring the Dissolution Behavior of Novel Pharmaceutical Cocrystals Consisting of Antimalarial Drug Artemisinin with Probe-Type Low-Frequency Raman Spectrometer: Kudo Ta, Miura S, Takatori K, Titapiwatanakun Vb, Palanisamy V, Yamamoto Ka, Ikeda Ya, Fukami T (aTakeda Pharmaceutical Company Limited, bFaculty of Pharmaceutical Sciences, Chulalongkorn University), Appl. Spectrosc. , 78, 1125-1135 (2024). https://doi.org/10.1177/00037028241275670
  2. 医薬品中に含まれるアスパルテームがフェニルケトン尿症患者に及ぼす影響（第2報）ジェネリック医薬品および同種・同効薬の比較: 鈴木柚衣南，岡本奈子，羽田敬宏a，石川洋一，深水啓朗 (a東大病院　薬剤部), 日本小児臨床薬理学会誌, 37, 80-90 (2024).
  3. Real-time quantitative evaluation of a drug during liposome preparation using a probe-type Raman spectrometer: Sato T, Haneishi K, Hisada H, Fujii M, Koide Ta, Fukami T (aDivision of Drugs, National Institute of Health Sciences), Langmuir, 40, 7962-7963 (2024). https://doi.org/10.1021/acs.langmuir.3c03872
  4. Quabodepistat (OPC-167832), a novel antituberculosis drug candidate: Enhancing oral bioavailability via cocrystallization and mechanistic analysis of bioavailability in two cocrystals: Sakamoto Na, Miyata Ka, Fukami T (aCMC Headquarters, Otsuka Pharmaceutical Co. Ltd.), Mol. Pharmaceutics, 21, 358-369 (2024). https://doi.org/10.1021/acs.molpharmaceut.3c01059


2023

原著論文 Original Articles

  1. Effects of wet granulation process variables on the quantitative assay model of transmission Raman spectroscopy for pharmaceutical tablets: Ohashi R, Koide Ta, Fukami T (aDivision of Drugs, National Institute of Health Sciences), Eur. J. Pharm. Biopharm., 191, 276-289 (2023). https://doi.org/10.1016/j.ejpb.2023.09.009
  2. Pharmaceutical Evaluation of Levofloxacin Orally Disintegrating Tablet Formulation Using Low Frequency Raman Spectroscopy: Yamamoto Ya, Kajita Mb, Hirose Yb, Shimada N, Fukami T, Koide Tc (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bBio & Healthcare Division, HORIBA Ltd., cDivision of Drugs, National Institute of Health Sciences), Pharmaceutics, 15, 2041 (2023). https://doi.org/10.3390/pharmaceutics15082041
  3. Novel vesicles composed of gemini-type amphiphiles, glycolipid biosurfactants, and cholesterol improve skin permeability of anti-inflammatory drugs and restore viability of damaged 3D-cultured skin: Terayama Sa, Tamura R, Fukami T (aMilott Cosmetic Corporation), J. Drug Deriv. Sci. Technol., 84, 104499 (2023). https://doi.org/10.1016/j.jddst.2023.104499
  4. Evaluation of the effect of disintegrant distribution on the dissolution behavior of pharmaceutical tablets using Raman chemical imaging: Kondo A, Koide Ta, Fukami T (aDivision of Drugs, National Institute of Health Sciences), Chem. Pharm. Bull., 71, 454-458 (2023).
  5. Exploring and characterization for novel cocrystal hydrate consisting of captopril; peptide-derived drug: Haku R, Takatori K, Suzuki Na, Ono M, Titapiwatanakun Vb, Fukami T (aSchool of Pharmacy, Nihon University, bFaculty of Pharmaceutical Sciences, Chulalongkorn University), CrystEngComm, 25, 2523-2533 (2023). https://doi.org/10.1039/D3CE00181D
  6. Internuclear distance measurements between 1H and 14N in multi-component rigid solids at fast MAS: Ogaeri Ya,b, Suzuki Nc, Fukami T, Nishiyama Ya,b (aJEOL Ltd., bRIKEN-JEOL Collaboration Center, RIKEN, cSchool of Pharmacy, Nihon University), J. Magn. Reson., 348, 107378 (2023). https://doi.org/10.1016/j.jmr.2023.107378
  7. Quality evaluation of humidified magnesium oxide tablet formulations with respect to disintegration time prolongation: Yamamoto Ya, Ohgi Kb,　Onuki Yb, Fukami T, Koide Tc (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bSchool of Pharmacy and Pharmaceutical Sciences, University of Toyama, cDivision of Drugs, National Institute of Health Sciences), Chem. Pharm. Bull., 71, 165-174 (2023). "Featured Article in Feb." https://doi.org/10.1248/cpb.c22-00798
  8. Quantitative Monitoring of Cocrystal Polymorphisms in Model Tablets Using Transmission Low-Frequency Raman Spectroscopy: Inoue M, Osada T, Hisada H, Koide Ta, Fukami T, Roy Ab, Carriere Jb (aDivision of Drugs, National Institute of Health Sciences, bCoherent Inc.), J. Pharm. Sci., 112, 225-229 (2023).　https://doi.org/10.1016/j.xphs.2022.09.009


2022

原著論文 Original Articles

  1. Quantitative evaluation of supersaturation of amorphous solid dispersion formulations with different drug/polymer combinations using mathematical modeling: Hirai Da, Tsunematsu Ha, Kimura Sa, Itai Sa, Fukami T, Iwao Ya, b (aUniversity of Shizuoka, bWakayama Medical University), Int. J. Pharm., 625, 122110 (2022).　https://doi.org/10.1016/j.ijpharm.2022.122110
  2. Amount of cholesterol in intercellular lipid models inversely correlates with hexagonal structure ratio in packing structures: Terayama Sa, Goto Y, Fukami T (aMilott Cosmetic Corporation), Chem. Eng. Sci., 259, 117814 (2022). https://doi.org/10.1016/j.ces.2022.117814
  3. Amorphous Characterization of Pharmaceutical Drug Substances Enabled by the Mechanical Properties of Atomic Force Microscope: Kimoto Ka, Ohashi K, Iwao Ya,b, Karashima Ma, Yamamoto Ka,c, Fukami T, Ikeda Ya,c (aTakeda Pharmaceutical Co., Ltd., bWakayama Medical University, cGraduate School of Pharmaceutical Sciences, Chiba University), Int. J. Pharm., 621, 121784 (2022). https://doi.org/10.1016/j.ijpharm.2022.121784
  4. Evaluation of the usefulness of hydroxypropyl cellulose and sucrose in the nasal influenza vaccine: Mieda Sa, Inoue Ka, Ito Aa, Yada Sa, Miyajima Ma, Fukami T (aDaiichi Sankyo Co., Ltd.), J. Drug Deliv. Sci. Technol., 69, 103165 (2022). https://doi.org/10.1016/j.jddst.2022.103165
  5. クロベタゾールプロピオン酸エステル軟膏の製剤特性およびヘパリン類似物質油性クリームとの混合物における基剤安定性に関する検証: 山本佳久a, 波田美咲a, 田中咲妃, 原口七海, 鈴木直人b, 深水啓朗, 小出達夫c (a帝京平成大学 薬学部, b日本大学 薬学部, c国立医薬品食品衛生研究所 薬品部), 薬学雑誌, 142, 421-430 (2022). https://doi.org/10.1248/yakushi.21-00223
  6. Non-destructive quantitative analysis of pharmaceutical ointment by transmission Raman spectroscopy: Ohashi R, Fujii A, Fukui K, Koide Ta, Fukami T (aDivision of Drugs, National Institute of Health Sciences), Eur. J. Pharm. Sci., 169, 106095 (2022). https://doi.org/10.1016/j.ejps.2021.106095


2021

原著論文 Original Articles

  1. Monitoring of Crystalline Transition During Wet Granulation Process Using Probe Type Low-frequency Raman Spectrometer: Fukui K, Suzuki Y, Haneishi K, Titapiwatanakun Va, Hisada H, Koide Tb, Fukami T (aFaculty of Pharmaceutical Sciences, Chulalongkorn University, bDivision of Drugs, National Institute of Health Sciences), Thai J. Pharm. Sci., 45, 340-343 (2021).
  2. Four Novel Pharmaceutical Cocrystals of Oxyresveratrol, Including a 2 : 3 Cocrystal with Betaine: Sakamoto N, Tsuno N, Koyama R, Gato K, Titapiwatanakun Va, Takatori K, Fukami T (aFaculty of Pharmaceutical Sciences, Chulalongkorn University), Chem. Pharm. Bull., 69, 995-1004 (2021). https://doi.org/10.1248/cpb.c21-00375
  3. Monitoring of Cocrystal Dissociation during the Wet Granulation Process in the Presence of Disintegrants by Using Low-Frequency Raman Spectroscopy: Suzuki Na, Fukui K, Otaka K, Suzuki Ta, Fukami T (aLaboratory of Pharmaceutics, School of Pharmacy, Nihon University), Chem. Pharm. Bull., 69, 271-277 (2021). https://doi.org/10.1248/cpb.c21-00302
  4. 医薬品中に含まれるアスパルテームがフェニルケトン尿症患者に及ぼす影響: 髙田裕奈, 草村把奈, 安武夫, 石川洋一, 深水啓朗, 小児臨床薬理学会雑誌, 34, 47-54 (2021).
  5. Pharmacokinetics of CuGTSM, a Novel Drug Candidate,in a Mouse Model of Menkes Disease: Yamagishi Ya, Kudo Ta, Oyumi Ma, Sakamoto Ya, Takahashi K, Akashi T, Kobayashi Sa, Kawakami Ta, Goda Ha, Sato Yb, Mimaki Mb, Kodama Hc, Munakata Md, Makino Ke, Takahashi He, Fukami T, Kiyomi Itoa (aResearch Institute of Pharmaceutical Sciences, Musashino University, bDepartment of Pediatrics, Teikyo University School of Medicine, cHealth and Dietetics, Teikyo Heisei University, Graduate School of Health, dDepartment of Pediatrics, Tohoku University School of Medicine, eDepartment of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science), Pharm. Res., 38, 1335-1344 (2021). https://doi.org/10.1007/s11095-021-03090-0
  6. Advanced Formulation Design for Topical Creams Assisted with Vibrational Spectroscopic Imaging: Ozawa Y, Watanabe Y, Ando Da, Koide Ta, Fukami T (aDivision of Drugs, National Institute of Health Sciences), Chem. Pharm. Bull., 69, 271-277 (2021). https://doi.org/10.1248/cpb.c20-00979
  7. Evaluation of the factors contributing to the stability of the mixture of heparinoid oil-based cream and droplet dispersion-type ointment: Yamamoto Ya, Ozutsumi Aa, Miwa Ea, Fukami T, Koide Tb (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bDivision of Drugs, National Institute of Health Sciences), J. Drug Deliv. Sci. Technol., 61, 102218 (2021). https://doi.org/10.1016/j.jddst.2020.102218
  8. Solid-State Analysis of Alpha-Cyclodextrin Inclusion Complexes Using Low-Frequency Raman Spectroscopy: Inoue M, Hisada H, Takatori K, Koide Ta, Fukami T, Roy Ab, Carriere Jb (aDivision of Drugs, National Institute of Health Sciences, bCoherent Inc.), Anal. Chem., 93, 704-708 (2021). https://doi.org/10.1021/acs.analchem.0c03854


2020

原著論文 Original Articles

  1. Mechanistic study of preparation of drug/polymer/surfactant ternary hot extrudates to obtain small and stable drug nanocrystal suspensions: Omagari Ka, Ueda Ka, Zhijinga Za, Higashi Ka, Inoue M, Fukami T, Moribe Ka (aGraduate School of Pharmaceutical Sciences, Chiba University), Int. J. Pharm., 591, 120003, (2020). https://doi.org/10.1016/j.ijpharm.2020.120003
  2. アクリルポリマーを用いた鎮痛消炎貼付剤の製剤学的特性に関する研究: 我藤勝彦, 四角凌悟, 加藤秀, 藤井美佳, 小出達夫a, 深水啓朗 (a国立医薬品食品衛生研究所 薬品部), 薬学雑誌, 140, 1175-1183, (2020). https://doi.org/10.1248/yakushi.20-00108
  3. Molecular state evaluation of active pharmaceutical ingredients in adhesive patches for transdermal drug delivery: Gato K, Yoshimura Fujii M, Hisada H, Carriere Ja, Koide Tb, Fukami T (aCoherent Inc., bDivision of Drugs, National Institute of Health Sciences), J. Drug Deliv. Sci. Technol., 58, 101800, (2020). https://doi.org/10.1016/j.jddst.2020.101800
  4. Physical characteristics of cilostazol-hydroxybenzoic acid cocrystals prepared using a spray drying method: Urano Ma, Kitahara Ma, Kishi Ka, Goto Ea, Tagami Ta, Fukami T, Ozeki Ta (aDrug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University), Crystals, 10, 313 (2020). https://doi.org/10.3390/cryst10040313
  5. Comparison of various pharmaceutical properties of clobetasol propionate cream formulations - considering stability of mixture with moisturizer-: Yamamoto Ya, Onuki Yb, Fukami T, Koide Tc (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bFaculty of Pharmacy and Pharmaceutical Sciences, University of Toyama, cDivision of Drugs, National Institute of Health Sciences), J. Pharm. Health Care Sci., 5, 1, (2020). https://doi.org/10.1186/s40780-020-0158-y
  6. The effect of preparation temperature on the microstructure of intercellular lipid models in stratum corneum: Yoshimura Fujii Ma, Gato K, Ozawa Y, Hisada H, Koide T, Inoue M, Fukami T (aMilott Cosmetic Corporation), Eur. J. Lipid Sci. Technol., 122, 1900171 (2020). https://doi.org/10.1002/ejlt.201900171
  7. Crystal structure analysis and pharmaceutical properties of amide salts consisting of paracetamol/sulfonic acids as solid forms prepared by grinding: Suzuki Na, Kanazawa Ta, Takatori K, Suzuki Ta, Fukami T (aSchool of Pharmacy, Nihon Uiversity), Cryst. Growth Des., 20, 590-599 (2020). https://doi.org/10.1021/acs.cgd.9b00763
  8. Determining the Distribution of Active Pharmaceutical Ingredients in Combination Tablets Using Near IR and Low-Frequency Raman Spectroscopy Imaging: Hisada H, Okayama A, Hoshino T, Carriere Ja, Koide Tb, Yamamoto Yc, Fukami T (aCoherent Inc., bDivision of Drugs, National Institute of Health Sciences, cFaculty of Pharmaceutical Sciences, Teikyo Heisei University), Chem. Pharm. Bull., 68, 155-160 (2020). https://doi.org/10.1248/cpb.c19-00791
  9. In Situ Monitoring of the Crystalline State of Active Pharmaceutical Ingredients during High-shear Wet Granulation Using a Low-frequency Raman Probe: Nomura K, Titapiwatanakun Va, Hisada H, Koide Tb, Fukami T (aFaculty of Pharmaceutical Sciences, Chulalongkorn University, bDivision of Drugs, National Institute of Health Sciences), Eur. J. Pharm. Biopharm., 147, 1-9 (2020). https://doi.org/10.1016/j.ejpb.2019.12.004
  10. Potential application of novel liquid crystal nanoparticles of isostearyl glyceryl ether for 4-biphenyl acetic acid transdermal delivery: Yoshimura Fujii M, Asakawa Y, Fukami T, Int. J. Pharm., 575, 118935 (2020). https://doi.org/10.1016/j.ijpharm.2019.118935
  11. Quantification of Cocrystal and its Dissociated Compounds in Solid Dosage Forms by Using Transmission Raman Spectroscopy: Koide Ta, Takeuchi Y, Otaki Tb, Yamamoto Kb, Shimamura R, Ohashi R, Inoue M, Fukami T, Izutsu Ka (aDivision of Drugs, National Institute of Health Sciences, bAnalytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited), J. Pharm. Biomed. Anal., 177, 112886 (2020). https://doi.org/10.1016/j.jpba.2019.112886


2019

原著論文 Original Articles

  1. 製剤中に含まれる乳糖の乳糖不耐患者に及ぼす影響に関する検討: 草村把奈, 丹沢彩乃a, 高田裕奈, 安武夫, 石川洋一, 深水啓朗 (a国立成育医療研究センター), 日本小児臨床薬理学会雑誌32, 113-117 (2019).
  2. Comparative Evaluation of the Photostability of Carbamazepine Polymorphs and Cocrystals: Yutani Ra, Haku R, Teraoka Ra,b, Tode Cc, Koide Td, Kitagawa Se, Sakane Ta, Fukami T (aLaboratory of Pharmaceutical Technology, Kobe Pharmaceutical University, bDepartment of Pharmaceutical Technology, College of Pharmaceutical Sciences, Himeji Dokkyo University, cInstrumental Analysis Center, Kobe Pharmaceutical University, dDivision of Drugs, National Institute of Health Sciences, eKobe Pharmaceutical University), Crystals9, 553 (2019). doi:10.3390/cryst9110553
  3. Solid-State Quantification of Cocrystals in Pharmaceutical Tablets Using Transmission Low-Frequency Raman Spectroscopy: Inoue M, Osada T, Hisada H, Koide Ta, Fukami T, Roy Ab, Carriere Jb, Heyler Rb (aDivision of Drugs, National Institute of Health Sciences, bCoherent Inc.), Anal. Chem. 91, 13427-13432 (2019). https://doi.org/10.1021/acs.analchem.9b01895
  4. Evaluation of the water content and skin permeability of active pharmaceutical ingredients in ketoprofen poultice formulations removed from their airtight containers and left at room temperature: Yamamoto Ya, Yamauchi Rb, Ohno Sb, Asai Kb, Fukami T, Koide Tc (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bDivision of Pharmaceutical Education and Research, Hoshi University, cDivision of Drugs, National Institute of Health Sciences), Biol. Pharm. Bull. 42, 2102-2108 (2019). https://doi.org/10.1248/bpb.b19-00758
  5. Imaging Analysis Enables to Differentiate Distribution of Pharmaceutical Ingredients in Tacrolimus Ointments: Yoshimura Fujii Ma, Yamamoto Yb, Koide Tc, Hamaguchi Md, Onuki Yd, Suzuki Ne, Suzuki Te, Fukami T (aMilott Cosmetic Corporation, bFaculty of Pharmaceutical Sciences, Teikyo Heisei University, cDivision of Drugs, National Institute of Health Sciences, dFaculty of Pharmacy and Pharmaceutical Science, University of Toyama, eSchool of Pharmacy, Nihon University), Appl. Spectrosc. 73, 1183-1192 (2019). https://doi.org/10.1177/0003702819863441
  6. Pharmaceutical Quantification with Univariate Analysis Using Transmission Raman Spectroscopy: Shimamura R, Koide Ta, Hisada H, Inoue M, Fukami T, Katori Na, Goda Ya (aDivision of Drugs, National Institute of Health Sciences), Drug Devel. Ind. Pharm. 45, 1430-1436 (2019). https://doi.org/10.1080/03639045.2019.1621336
  7. Measurement of the Water Content in Semi-solid Formulations Used to Treat Pressure Ulcers and Evaluation of Their Water Absorption Characteristics: Hoshino T, Azuma M, Yamada Ya, Titapiwatanakun Vb, Yoshimura Fujii M, Yamamoto Ya, Koide Tc, Fukami T (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bFaculty of Pharmaceutical Sciences, Chulalongkorn University, cDivision of Drugs, National Institute of Health Sciences), Chem. Pharm. Bull. 67, 929-934 (2019). https://doi.org/10.1248/cpb.c18-00746
  8. Improving the solid-state photostability of furosemide by its cocrystal formation: Teraoka Ra,b, Fukami T, Furuishi Tc, Nagase Hc, Ueda Hc, Tode Cd, Yutani Rb, Kitagawa Se, Sakane Tb (aCollege of Pharmaceutical Sciences, Himeji Dokkyo University, bLaboratory of Pharmaceutical Technology, Kobe Pharmaceutical University, cSchool of Pharmacy and Pharmaceutical Sciences, Hoshi University, dInstrumental Analysis Center, Kobe Pharmaceutical University, eKobe Pharmaceutical University), Chem. Pharm. Bull. 67, 940-944 (2019). https://doi.org/10.1248/cpb.c18-00812
  9. Exploring Novel Cocrystalline Forms of Oxyresveratrol to Enhance Aqueous Solubility and Permeability across a Cell Monolayer: Suzuki Y, Muangnoi Ca, Thaweesest Wa, Teerawonganan Pa, Na Bhuket R Pa, Titapiwatanakun Vb, Yoshimura-Fujii M, Sritularak Ba,b, Likhitwitayawuid Kb, Rojsitthisak Pa,b, Fukami T (aNatural Products for Ageing and Chronic Diseases Research Unit, Chulalongkorn University, bFaculty of Pharmaceutical Sciences, Chulalongkorn University, Biol. Pharm. Bull. 42, 1004-1012 (2019). https://doi.org/10.1248/bpb.b19-00048
  10. Evaluation of the three-dimensional distribution of droplets in a droplet dispersion-type ointment using confocal Raman microscopy: Yamamoto Ya, Yoshimura-Fujii Mb, Fukami T, Koide Tc (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bMilott Cosmetic Corporation, cDivision of Drugs, National Institute of Health Sciences), J. Drug Deliv. Sci. Technol.51, 639-642 (2019). https://doi.org/10.1016/j.jddst.2019.04.003
  11. Screening a trace amount of pharmaceutical cocrystals by using an enhanced nano-spot method: Tanabe Y, Maeno Ya, Ohashi K, Hisada H, Roy Ab, Carriere Jb, Heyler Rb, Fukami T (aAnalysis Research Department, Nissan Chemical Corporation, bCoherent Inc.), Eur. J. Pharm. Biopharm. 136, 131-137 (2019). https://doi.org/10.1016/j.ejpb.2019.01.018
  12. Transmission Low-Frequency Raman Spectroscopy for Quantification of Crystalline Polymorphs in Pharmaceutical Tablets: Inoue M, Hisada H, Koide Ta, Fukami T, Roy Ab, Carriere Jb, Heyler Rb (aDivision of Drugs, National Institute of Health Sciences, bOndax Inc.), Anal. Chem. 91, 1997-2003 (2019). https://doi.org/10.1021/acs.analchem.8b04365
  13. 小児用粉状製剤を服用するためのペースト状態に必要な最適水量：降伏値に基づいた考察と後発医薬品への適用: 福田春香a, 鈴木豊史b, 橋崎 要b, 吉村彩也香b, 小林千翔b, 重谷美子a, 鈴木直人b, 金沢貴憲b, 深水啓朗, 山本佳久c (a株式会社アイリスファーマ, b日本大学 薬学部, c帝京平成大学 薬学部), 薬学雑誌 139, 299-308 (2019). https://doi.org/10.1248/yakushi.18-00182


2018

原著論文 Original Articles

  1. Mixtures of betamethasone butyrate propionate ointments and heparinoid oil-based cream: Physical stability evaluation: Yamamoto Ya, Hanai Aa, Onuki Yb, Fujii M, Onishi Y, Fukami T, Metori Kc, Suzuki Nc, Suzuki Tc, Koide Td (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bFaculty of Pharmacy and Pharmaceutical Science, University of Toyama, cSchool of Pharmacy, Nihon University, dDivision of Drugs, National Institute of Health Sciences), Eur. J. Pharm. Sci. 124, 199-207 (2018).
  2. Molecular state of active pharmaceutical ingredients in ketoprofen dermal patches characterized by pharmaceutical evaluation: Azuma M, Fujii M, Inoue M, Hisada H, Koide Ta, Kemper Mb, Yamamoto Yc, Suzuki Nd, Suzuki Td, Fukami T (aDivision of Drugs, National Institute of Health Sciences, bTornado Spectral Systems, Inc., cFaculty of Pharmaceutical Sciences, Teikyo Heisei University, dSchool of Pharmacy, Nihon University), Biol. Pharm. Bull. 41, 1348-1354 (2018).
  3. In situ monitoring of cocrystals in formulation development using low-frequency Raman spectroscopy: Otaki Ta, Tanabe Y, Kojima Ta, Miura Ma, Ikeda Ya, Koide Tb, Fukami T (aTakeda Pharmaceutical Company Limited, bDivision of Drugs, National Institute of Health Sciences), Int. J. Pharm. 542, 56-65 (2018).
  4. Discrimination and Quantification of Sulfathiazole Polytypes Using Low-frequency Raman Spectroscopy: Iwata Ka, Karashima Ma, Ikeda Ya, Inoue M, Fukami T (aTakeda Pharmaceutical Company Limited), Cryst. Eng. Comm. 20, 1928-1934 (2018).
  5. 日本薬局方の医薬品各条における確認試験を志向したラマン分光法の実用性: 久田浩史, 佐久間発, 大西優, 井上元基, 牟田史仁a, 深水 啓朗 (a株式会社リガク), 製剤機械技術学会誌 27, 5-12 (2018).
  6. Comparison of the Relative Stability of Pharmaceutical Cocrystals Consisting of Paracetamol and Dicarboxylic Acids: Suzuki Na, Kawahata Mb, Yamaguchi Kb, Suzuki Ta, Tomono Ka, Fukami T (aLaboratory of Pharmaceutics, School of Pharmacy, Nihon University, bFaculty of Pharmaceutical Sciences, Tokushima Bunri University Kagawa Campus), Drug Devel. Ind. Pharm.44, 582-589 (2018).


2017

原著論文 Original Articles

  1. Impact of the dissolution profile of the cilostazol cocrystal with supersaturation on the oral bioavailability: Yoshimura Ma,b, Miyake Ma, Kawato Ta, Bando Ma, Kato Ya, Fukami T, Ozeki Tb (aOtsuka Pharmaceutical Co.,Ltd.,b Graduate School of Pharmaceutical Sciences, Nagoya City University), Cryst. Growth Des.17, 550-557 (2017)
  2. In situ monitoring of crystalline transformation of carbamazepine using probe type low frequency Raman spectroscopy: Inoue M, Hisada H, Koide Ta, Carriere Jb, Heyler Rb, Fukami T (aDivision of Drugs, National Institute of Health Sciences, bOndax Inc.), Org. Process Res. Dev.21, 262-265 (2017)
  3. Stability of mixed preparation consisting of commercial moisturizing creams with an ointment base investigated by magnetic resonance imaging: Onuki Ya, Funatani Cb, Yamamoto Yc, Fukami T, Koide Td, Hayashi Ya, Takayama Kb (aFaculty of Pharmacy and Pharmaceutical Science, University of Toyama, bDepartment of Pharmaceutics, Hoshi University,cFaculty of Pharmaceutical Science, Teikyo Heisei University,d Division of Drugs, National Institute of Health Sciences), Chem. Pharm. Bull. 65, 487-491 (2017)
  4. Novel amino acid-based surfactant for silicone emulsification and its application in hair care products: a promising alternative to quaternary ammonium cationic surfactants: Fujii M, Inoue M, Fukami T, Int. J. Cosmet. Sci.39, 556-563 (2017)
  5. Comparison of pharmaceutical properties among clobetasol propionate cream formulations: Considerations from near infrared spectra: Yamamoto Ya, Fukami T, Onuki Yb, Metori Kc, Suzuki Td,Koide Te (aFaculty of Pharmaceutical Science, Teikyo Heisei University,bFaculty of Pharmacy and Pharmaceutical Science, University of Toyama, cChemical Analysis Center, Research Institute of Pharmacy, Nihon University, d Laboratory of Pharmaceutics, School of Pharmacy, Nihon University, eDivision of Drugs, National Institute of Health Sciences),Vib. Spectrosc.93, 17-22 (2017)
  6. 共結晶を含む医薬品のレギュレーションに関する考察と一提言－共結晶体は原薬か製剤中間体か: 深水啓朗, 谷田智嗣a, 小出達夫b, 我藤勝彦c, 小野誠d, 岩尾康範e, 東顕二郎f, 池田幸弘g, 米持悦生h (a中外製薬株式会社 研究本部, b国立医薬品食品衛生研究所 薬品部, cアステラス製薬株式会社 技術本部 物性研究所, d 第一三共株式会社 製薬技術本部 分析評価研究所, e静岡県立大学薬学部 創剤工学教室, f千葉大学大学院薬学研究院 製剤工学研究室, g武田薬品工業株式会社ファーマシューティカル・サイエンス アナリティカル・デベロップメント, h星薬科大学 薬品物理化学教室), 医薬品医療機器レギュラトリーサイエンス48, 850-855 (2017)
  7. Real-Time Formation Monitoring of Cocrystals with Different Stoichiometries Using Probe-Type Low-Frequency Raman Spectroscopy: Inoue M, Hisada H, Koide Ta, Carriere Jb, Heyler Rb, Fukami T (aDivision of Drugs, National Institute of Health Sciences, bOndax Inc.), Ind. Eng. Chem. Res.56, 12693-12697 (2017)


2016

原著論文 Original Articles

  1. Pharmaceutical evaluation of atorvastatin calcium tablets available on the Internet: a preliminary investigation of substandard medicines in Japan: Fukami T, Koide Ta, Hisada H, Inoue M, Yamamoto Yb, Suzuki Tc, and Tomono Kc, (aDivision of Drugs, National Institute of Health Sciences, bFaculty of Pharmaceutical Science, Teikyo Heisei University, cSchool of Pharmacy, Nihon University), J. Drug Deliv. Sci. Technol.31, 35-40 (2016)
  2. Analysis of the stability of external-application dermatologic preparations: consideration from rheological measurement: Yamamoto Ya, Kumetani Ma, Onuki Yb, Koide Tc, Suzuki Td, Fukami T, (aFaculty of Pharmaceutical Science, Teikyo Heisei University, b Faculty of Pharmacy and Pharmaceutical Science, University of Toyama, c Division of Drugs, National Institute of Health Sciences,d School of Pharmacy, Nihon University),Chem. Pharm. Bull. 64, 1047-1055 (2016)
  3. Involvement of a proton-coupled organic cation antiporter in the blood-brain barrier transport of amantadine: Suzuki Ta, Aoyama Ta, Suzuki Na, Fukami T, Matsumoto Ya, Tomono Ka (aSchool of Pharmacy, Nihon University), Biopharm. Drug Dispos. 37, 323-335 (2016)
  4. Characterization and quality control of pharmaceutical cocrystals (Review article): Izutsu Ka, Koide Ta, Takata Nb, Ikeda Yc, Ono Md, Inoue M, Fukami T, Yonemochi Ee, (a National Institute of Health Sciences, b Research Division, Chugai Pharmaceutical Co., Ltd., c Analytical Development Laboratories, CMC Center, Takeda Pharmaceutical Co., Ltd., d Analytical & Quality Evaluation Research Laboratories, Daiichi-Sankyo Co., Ltd., e School of pharmacy and Pharmaceutical Sciences, Hoshi University), Chem. Pharm. Bull. 64, 1421-1430 (2016)
  5. Solid dispersions of efonidipine hydrochloride ethanolate with improved physicochemical and pharmacokinetic properties prepared with microwave treatment: Otsuka Ma,Maeno Ya, Fukami T, Inoue M, Tagami Tb and Ozeki Tb (aAnalysis Research Department, Chemical Research Laboratories, Nissan Chemical Industries, Ltd., b Graduate School of Pharmaceutical Sciences, Nagoya City University), Eur. J. Pharm. Biopharm. 108, 25-31 (2016)
  6. Microanalysis of pharmaceutical cocrystals using a nano-spot method coupled with Raman spectroscopy: Maeno Ya, Inoue M, Suzuki Tb, Tomono Kb, Fukami T, (aAnalysis Research Department, Nissan Chemical Industries, Ltd.,b Laboratory of Pharmaceutics, School of Pharmacy, Nihon University),CrystEngComm18, 8004-8009 (2016)
  7. Identification of pseudopolymorphism of magnesium stearate by using low frequency Raman spectroscopy: Koide Ta, Fukami T, Hisada H, Inoue M, Carriere Jb, Heyler Rb, Katori Na, Okuda Ha, Goda Ya(aDivision of Drugs, National Institute of Health Sciences, bOndax Inc.), Org. Process Res. Dev.20, 1906-1910 (2016)


2015

原著論文 Original Articles

  1. Possible involvement of cationic-drug sensitive transport systems in the blood-to-brain influx and brain-to-blood efflux of amantadine across the blood-brain barrier: Suzuki Ta, Fukami T and Tomono Ka (aSchool of Pharmacy, Nihon University), Biopharm. Drug Dispos. 36, 126-137 (2015)
  2. ヘパリン類似物質含有軟膏の塗布におけるエルロチニブ誘発皮膚障害の発現時期に及ぼす性別の影響: 宗 村盛a, 鈴木豊史b, 藤井瑞恵a, 井上真由美a, 長島修c, 深水啓朗, 伴野和夫b，(a順天堂大学医学部附属順天堂東京江東高齢者医療センター薬剤科, b日本大学薬学部薬剤学研究室c順天堂大学医学部附属順天堂東京江東高齢者医療センター呼吸器内科), 日病薬師会誌 51, 216-219 (2015)
  3. Studies on Uniformity of the Active Ingredients in Acetaminophen Suppositories Re-solidified after Melting under High Temperature Conditions: Yamamoto Ya, Fukami T, Koide Tb, Onuki Yc, Suzuki Td, Katori Nb and Tomono Kd (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bDivision of Drugs, National Institute of Health Sciences, cDepartment of Pharmaceutics, Hoshi University, dSchool of Pharmacy, Nihon University), Chem. Pharm. Bull. 63, 263-272 (2015)
  4. Magnetic Resonance Imaging of the Phase Separation in Mixed Preparations of Moisturizing Cream and Steroid Ointment after Centrifugation: Onuki Ya, Funatani Ca, Yokowa Tb, Yamamoto Yc, Fukami T, Koide Td, Obata Ya and Takayama Ka (aDepartment of Pharmaceutics, Hoshi University, bBio View Corporation, cFaculty of Pharmaceutical Sciences, Teikyo Heisei University, dDivision of Drugs, National Institute of Health Sciences), Chem. Pharm. Bull. 63, 326-329 (2015)
  5. 医薬品の原薬形態である塩と共結晶のレギュレーションに関する現状と提言:深水啓朗, 山下博之a, 小野誠b, 池田幸弘c (aアステラス製薬株式会社 研究本部 薬物動態研究所, b第一三共株式会社 製薬技術本部 分析評価研究所, c武田薬品工業株式会社 CMC研究センター 開発分析研究所), 医薬品医療機器レギュラトリーサイエンス46, 326-329 (2015)
  6. Analysis of Distribution of Ingredients in the Clarithromycin Tablet in the Market by Using Near-Infrared Chemical Imaging with Principal Component Analysis and Partial Least Squares: Koide Ta, Yamamoto Yb, Fukami T, Katori Na, Okuda Ha and Hiyama Ya (aDivision of Drugs, National Institute of Health Sciences, bFaculty of Pharmaceutical Sciences, Teikyo Heisei University), Chem. Pharm. Bull. 63, 663-668 (2015)
  7. Determination and prediction of solubilities of active pharmaceutical ingredients in selected organic solvents: Matsuda Ha, Mori Ka, Tomioka Ma, Kariyasu Na, Fukami T, Kurihara Ka, Tochigi Ka and Tomono K b, (aDepartment of Materials and Applied Chemistry, Nihon University, bSchool of Pharmacy, Nihon University), Fluid Phase Equilibria 406, 116-123 (2015)
  8. Developmental considerations for ethanolates with regard to stability and physicochemical characterization of efonidipine hydrochloride ethanolate: Otsuka Ma,Maeno Ya, Fukami T, Inoue M, Tagami Tb and Ozeki Tb (aAnalysis Research Department, Chemical Research Laboratories, Nissan Chemical Industries, Ltd., b Graduate School of Pharmaceutical Sciences, Nagoya City University), CrystEngComm. 17, 7430-7436 (2015)
  9. Direct High-Resolution Imaging of Crystalline Components in Pharmaceutical Dosage Forms Using Low-Frequency Raman Spectroscopy: Hisada H, Inoue M, Koide Ta, Carriere Jb, Heyler Rb, and Fukami T (aDivision of Drugs, National Institute of Health Sciences, bOndax Inc.), Org. Process Res. Dev.19, 1796-1798 (2015)


2014

原著論文 Original Articles

  1. Comparative pharmaceutical evaluation of brand and genericclobetasone butyrate ointments: Yamamoto Ya, Fukami T, Koide Tb, Onuki Yc, Suzuki Td, Metori Kd, Katori Nb, Hiyama Yb and Tomono Kd (aFaculty of Pharmaceutical Sciences, Teikyo Heisei University, bDivision of Drugs, National Institute of Health Sciences, cDepartment of Pharmaceutics, Hoshi University, dSchool of Pharmacy, Nihon University), Int. J. Pharm. 463, 62-67 (2014)
  2. Novel pharmaceutical cocrystal consisting of paracetamol and trimethylglycine, a new promising cocrystal former: Maeno Ya, Fukami T, Kawahata Mb, Yamaguchi Kb, Tagami Tc, Ozeki Tc, Suzuki Td and Tomono Kd (aAnalysis Research Department, Chemical Research Laboratories, Nissan Chemical Industries, Ltd., bFaculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, cGraduate School of Pharmaceutical Sciences, Nagoya City University, dSchool of Pharmacy, Nihon University), Int. J. Pharm. 473, 179-186 (2014)

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